ITPR2 polyclonal, anti-human, mouse, rat

Background:
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production.

Alternative Name:
IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2, 4, 5-trisphosphate receptor, Inositol 1 4 5 trisphosphate receptor type 2, Inositol 1, 4, 5-trisphosphate receptor type 2, Inositol 145 trisphosphate receptor type 2, InsP3 R2, InsP3R2, IP3 R2, IP3 receptor, IP3 receptor isoform 2, IP3R 2, IP3R2, ITPR 2, Itpr2, ITPR2, Type 2 inositol 1 4 5 trisphosphate receptor, Type 2 inositol 1, Type 2 inositol 145 trisphosphate receptor, Type 2 InsP3 receptor,

Application Dilution:
DotBlot:1:2,000-1:5,000
ICC:1:50-1:100
IHC:1:50-1:200
FC:1:50-1:100

Specificity: ITPR2 polyclonal antibody detects endogenous levels of ITPR2 protein.

Immunogen:
Recombinant protein within human ITPR2 aa 1100-1450.

MW: 308 kDa

Swiss-Prot: Q14571(Human) Q9Z329(Mouse) P29995(Rat)

Purification & Purity:
Protein affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.