ITPR3 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

Description:
Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
4 antibody, 5-trisphosphate receptor antibody, 5-trisphosphate receptor type 3 antibody, FLJ36205 antibody, Inositol 1 antibody, Inositol 1,4,5 trisphosphate receptor type 3 antibody, InsP3R3 antibody, IP3 receptor antibody, IP3 receptor isoform 3 antibody, IP3R 3 antibody, IP3R antibody, IP3R3 antibody, ITPR 3 antibody, ITPR3 antibody, ITPR3_HUMAN antibody, Type 3 inositol 1 antibody, Type 3 inositol 1,4,5 trisphosphate receptor antibody, Type 3 InsP3 receptor antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3 (70-95aa QYWKAKQTKQDKEKIADVVLLQKLQH), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.