JAB1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
COP9 constitutive photomorphogenic homolog subunit 5(Arabidopsis), also known as COPS5 or JAB1, is a gene conserved from humans to Saccharomyces cerevisiae. It is a member of the MOV34 family. COPS5 is mapped to 8q13.1. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. COPS5 can interact with the cytoplasmic domain of the beta-2 subunit of the alpha-L/beta-2 integrin LFA1, and it is the only protein demonstrated to interact with MIF. COPS5, VHL, and TRC8 proteins appear to be linked both physically and functionally, and all 3 may participate in the development of kidney cancer. In addition to that, COPS5 is an essential cofactor for the apoptotic function of E2F1.

Description:
Rabbit IgG polyclonal antibody for COP9 signalosome complex subunit 5 (COPS4) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
38 kDa Mov34 homolog antibody, COP9(constitutive photomorphogenic) homolog subunit 5 antibody, COP9 constitutive photomorphogenic homolog subunit 5 antibody, COP9 signalosome complex subunit 5 antibody, COP9 signalosome subunit 5 antibody, Cop9 subunit 5 antibody, COPS 5 antibody, COPS5 antibody, CSN 5 antibody, CSN5 antibody, JAB 1 antibody, Jun activation domain binding protein 1 antibody, Jun activation domain binding protein antibody, Jun activation domain-binding protein 1 antibody, Jun activation domain-binding protein antibody, MGC3149 antibody, MOV 34 antibody, MOV34 antibody, MOV34 family, 38-KD member antibody, SGN 5 antibody, SGN5 antibody, Signalosome subunit 5 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human JAB1(318-334aa LMSQVIKDKLFNQINIS), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.