JAK1 (phospho-Y1022) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4108
Background:
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Alternative Name:
Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B
Application Dilution: IHC: 1:50~1:200
Specificity: p-JAK1 (Y1022) polyclonal antibody detects endogenous levels of JAK1 protein only when phosphorylated at Tyr1022.
Immunogen:
Synthetic phosphopeptide derived from human JAK1 around the phosphorylation site of Tyrosine 1022.
MW: ~ 132 kDa
Swis Prot.: P23458
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Alternative Name:
Tyrosine-protein kinase JAK1, Janus kinase 1, JAK-1, JAK1, JAK1A, JAK1B
Application Dilution: IHC: 1:50~1:200
Specificity: p-JAK1 (Y1022) polyclonal antibody detects endogenous levels of JAK1 protein only when phosphorylated at Tyr1022.
Immunogen:
Synthetic phosphopeptide derived from human JAK1 around the phosphorylation site of Tyrosine 1022.
MW: ~ 132 kDa
Swis Prot.: P23458
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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