JAK1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
JAK1(JANUS KINASE 1) is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. JAK1 is a member of a new class of PTKs that are a large family of proteins characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain--hence the name Janus. The JAK1 gene is mapped to 1p31.3. JAK1 is also important for transducing a signal by type I(IFN-alpha/beta) and type II(IFN-gamma) interferons, and members of the IL-10 family via type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.

Description:
Rabbit IgG polyclonal antibody for Tyrosine-protein kinase JAK1 (JAK1) detection. Tested with WB in Human, Mouse, Rat.

Synonyms:
EC 2.7.10.2 antibody, JAK 1 antibody, JAK 1A antibody, JAK 1B antibody, JAK-1 antibody, JAK1 antibody, JAK1_HUMAN antibody, JAK1A antibody, JAK1B antibody, Janus kinase 1(a protein tyrosine kinase) antibody, Janus Kinase 1 antibody, JTK3 antibody, Tyrosine protein kinase JAK 1 antibody, Tyrosine protein kinase JAK1 antibody, Tyrosine-protein kinase JAK1 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human JAK1(970-984aa KNKNKINLKQQLKYA), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human.
Predicted to work with: mouse, rat.

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.