JAK2 (phospho-Y1007) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4109
Background:
Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Alternative Name:
JAK 2, JAK-2, JAK2, Janus Activating Kinase 2, Janus Kinase 2, Janus Kinase 2, JTK 10, JTK10,
Application Dilution: IHC: 1:50~1:200
Specificity: p-JAK2 (Y1007) polyclonal antibody detects endogenous levels of JAK2 protein when phosphorylated at Tyr1007.
Immunogen:
Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 1007.
MW: ~ 125 kDa
Swis Prot.: O60674
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Jak2 (Janus Kinase 2) belongs to the emerging family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of STAT transcription factors to cytokine receptor-associated Jak2. Jak2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical Jak-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Altering Jak-STAT signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.
Alternative Name:
JAK 2, JAK-2, JAK2, Janus Activating Kinase 2, Janus Kinase 2, Janus Kinase 2, JTK 10, JTK10,
Application Dilution: IHC: 1:50~1:200
Specificity: p-JAK2 (Y1007) polyclonal antibody detects endogenous levels of JAK2 protein when phosphorylated at Tyr1007.
Immunogen:
Synthetic phosphopeptide derived from human JAK2 around the phosphorylation site of Tyrosine 1007.
MW: ~ 125 kDa
Swis Prot.: O60674
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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