Jarid1c polyclonal, anti-human antibody
€215.00
In stock
SKU
AC-ABV11389-50
Catalog Number: AC-ABV11389-50
Size: 50 µl
Host: Rabbit IgG
Applications: WB, E
Datasheet
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Size: 50 µl
Host: Rabbit IgG
Applications: WB, E
Datasheet
Request Information
Background:
Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation.
Other Names:
KDM5C, MRXJ, MRXSJ, SMCX, XE169
Primary Accession: P41229
Gene Name: KDM5C (HGNC:11114)
Gene ID: 8242
Jarid1c is a histone demethylase which specifically demethylates lysine 4 of histone H3, thereby playing a central role in the regulation of transcription and chromatin remodelling. Jarid1c demethylates the trimethylated and dimethylated lysine 4, but not the monomethylated form. Further, Jarid1c participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Mutations in the Jarid1c gene have been associated with X-linked mental retardation.
Other Names:
KDM5C, MRXJ, MRXSJ, SMCX, XE169
Primary Accession: P41229
Gene Name: KDM5C (HGNC:11114)
Gene ID: 8242
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