JMJD2D polyclonal (C-term), anti-human
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In stock
SKU
AC-AP1028b
Catalog Number: AC-AP1028b
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10797
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10797
Applications: WB
Datasheet
Request Information
Background:
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
Lysine-specific demethylase 4D, 11411-, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, KDM4D, JHDM3D, JMJD2D
Target/Specificity:
This JMJD2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-516 amino acids from the C-terminal region of human JMJD2D.
Antigen Region:
484-516
Antigen Type: Synthetic Peptide
Gene Name: KDM4D
Gene ID: 55693
Primary Accession: Q6B0I6
NCBI Accession: NP_060509.2
Other Accession: Q0VF39
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
Lysine-specific demethylase 4D, 11411-, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, KDM4D, JHDM3D, JMJD2D
Target/Specificity:
This JMJD2D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 484-516 amino acids from the C-terminal region of human JMJD2D.
Antigen Region:
484-516
Antigen Type: Synthetic Peptide
Gene Name: KDM4D
Gene ID: 55693
Primary Accession: Q6B0I6
NCBI Accession: NP_060509.2
Other Accession: Q0VF39
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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