JMJD4 polyclonal (C-term), anti-human, mouse
€0.00
In stock
SKU
AC-AP1030B
Catalog Number: AC-AP1030B
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10802
Applications: WB, IHC-P
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB10802
Applications: WB, IHC-P
Datasheet
Request Information
Background:
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
Target/Specificity:
This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-455 amino acids from the C-terminal region of human JMJD4.
Antigen Region:
423-455
Antigen Type: Synthetic Peptide
Gene Name: JMJD4
Gene ID: 65094
Primary Accession: Q9H9V9
NCBI Accession: NP_001154937.1;NP_075383.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
Other Names:
JmjC domain-containing protein 4, Jumonji domain-containing protein 4, JMJD4
Target/Specificity:
This JMJD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 423-455 amino acids from the C-terminal region of human JMJD4.
Antigen Region:
423-455
Antigen Type: Synthetic Peptide
Gene Name: JMJD4
Gene ID: 65094
Primary Accession: Q9H9V9
NCBI Accession: NP_001154937.1;NP_075383.2
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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