JNK1/2/3 (phospho-T183) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4763
Background:
The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
Alternative Name:
JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2ALPHA, JNK2B, JNK2BETA, JNK3, JNK3A, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 8, MAPK 9, MAPK10, MAPK8, MAPK9, MGC50974, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 9,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-JNK1/2/3 (T183) polyclonal antibody detects endogenous levels of JNK1/2/3 protein only when phosphorylated at Thr183.
Immunogen:
Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Threonine 183.
MW: ~ 46,54 kDa
Swis Prot.: P45983/P45984/P53779
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38. JNK3 (MK10, MAPK10, PRKM10) is activated by pro-inflammatory cytokines and environmental stresss by phosphorylating transcription factors such as c-Jun and ATF2. This is important for AP-1 transcriptional activity regulation. JNK3 is crucial for neuronal apoptosis (stress-induced).
Alternative Name:
JNK 46, JNK 55, JNK, JNK1, JNK1A2, JNK2, JNK21B1/2, JNK2ALPHA, JNK2B, JNK2BETA, JNK3, JNK3A, MAP kinase 8, MAP kinase 9, MAP kinase p49 3F12, MAPK 8, MAPK 9, MAPK10, MAPK8, MAPK9, MGC50974, Mitogen activated protein kinase 10, Mitogen activated protein kinase 8, Mitogen activated protein kinase 9,
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200, IF: 1:50~1:200
Specificity: p-JNK1/2/3 (T183) polyclonal antibody detects endogenous levels of JNK1/2/3 protein only when phosphorylated at Thr183.
Immunogen:
Synthetic phosphopeptide derived from human JNK1 around the phosphorylation site of Threonine 183.
MW: ~ 46,54 kDa
Swis Prot.: P45983/P45984/P53779
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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