JNK1 (clone 1A4) mouse monoclonal, anti-human, mouse, rat

Backgroud: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]

Synonyms: AI849689, c Jun N terminal kinase 1, C-JUN kinase 1, c-Jun N-terminal kinase 1, EC 2.7.11.24, JAK 1A, JAK1A, JNK 1, JNK 46, JNK, JNK-46, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MAPK8, Mitogen activated protein kinase 8, Mitogen-activated protein kinase 8, MK08_HUMAN, p54 gamma, PRKM 8, PRKM8, Protein kinase JNK1, Protein kinase, mitogen-activated, 8, SAPK 1, SAPK gamma, SAPK1, Stress activated protein kinase JNK1, Stress-activated protein kinase 1, Stress-activated protein kinase JNK1, Tyrosine protein kinase JAK1 .

Gene Name: MAPK8

Gene ID: 5599

SwissProt ID: P45983

Purification: Affinity Purified

Storage: Store at 4°C short term. Aliquot and store at -20°C for 12 months. Avoid freeze/thaw cycles.