JNK1 polyclonal, anti-human, mouse, rat

Protein Family: Enzymes, Protein Kinases

Pathway and Disease: Folding, Sorting and Degradation, Signal Transduction, Cell Communication, Immune System, Endocrine System, Nervous and Sensory Systems, Development and Behavior, Infectious Diseases, Cancers

Description:
c-Jun N-terminal kinase 1 (JNK1) responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2. This regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK1 phosphorylates heat shock factor protein 4 (HSF4).

Alternate Names: JNK1, Mitogen-activated protein kinase 8, Stress-activated protein kinase JNK1, c-Jun amino-terminal kinase 1, c-Jun N-terminal kinase 1, JNK-46, MAPK8, MAP kinase 8, MAPK 8, PRKM8, SAPK1

Application Notes: E: 1:10,000-1:50,000; WB: 1:200-1:1,000; IHC: 1:50-1:200

Accession No.: P45983

Antigen: KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human JNK1.

Format: Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 0.5% BSA with 0.09% sodium azide. Antibody was purified by immunogen affinity chromatography.

Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.