JTB polyclonal, anti-human, mouse, rat

Background:
Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential.

Synonyms: HJTB, HSPC222, PAR, hJT, protein JTB

Cellular Location: Cytoplasm 

Immunogen:
A synthetic peptide of human JTB

Gene Symbol: JTB

Gene ID: 10899

Swiss prot: O76095

Calculated MW: 16/13kDa

Recommended dilution:
IHC 1:50-200

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.