JunB (phospho-S79) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4111
Background:
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family..
Alternative Name:
JunB, Jun B, Jun B proto oncogene, Transcription factor jun-B
Application Dilution: IHC: 1:50~1:200, IP:1:50~1:200
Specificity: p-JunB (S79) polyclonal antibody detects endogenous levels of JunB protein only when phosphorylated at Ser79 .
Immunogen:
Synthetic phosphopeptide derived from human JunB around the phosphorylation site of Serine 79.
MW: ~ 43 kDa
Swis Prot.: P17275
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family..
Alternative Name:
JunB, Jun B, Jun B proto oncogene, Transcription factor jun-B
Application Dilution: IHC: 1:50~1:200, IP:1:50~1:200
Specificity: p-JunB (S79) polyclonal antibody detects endogenous levels of JunB protein only when phosphorylated at Ser79 .
Immunogen:
Synthetic phosphopeptide derived from human JunB around the phosphorylation site of Serine 79.
MW: ~ 43 kDa
Swis Prot.: P17275
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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