JunB polyclonal, anti-human, mouse, rat

Background:
The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein along with c-Fos is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Two additional genes, Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family.

Alternative Name:
JUNB, Activator protein 1, AP 1, AP1, Jun B, Jun B proto oncogene, Jun B protooncogene, Junb, JunB proto oncogene, JunB protoncogene 9, JunB protooncogene, JUNB, Transcription factor jun B, Transcription factor jun-B, Transcription factor junB,

Application Dilution:
WB:1:1,000-1:2,000
ICC:1:50-1:200

Specificity: JunB polyclonal antibody detects endogenous levels of JunB protein.

Immunogen:
recombinant protein

MW: 43 kDa

Swiss-Prot: P17275(Human) P09450(Mouse) P24898(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.