JunD (phospho-S255) polyclonal, anti-human, mouse, rat
€328.00
In stock
SKU
BS4112
Background:
The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation.
Alternative Name:
Transcription factor jun-D, JUN D
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-JunD (S255) polyclonal antibody detects endogenous levels of JunD protein only when phosphorylated at Ser255
Immunogen:
Synthetic phosphopeptide derived from human JunD around the phosphorylation site of Serine 255.
MW: ~ 35 kDa
Swis Prot.: P17535
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
The activator protein-1 (AP-1) transcription factor consists of either Jun/Jun homodimers or Fos/Jun heterodimeric complexes. Homo- and heterodimers bind to the TGACTCA consensus sequence present in numerous promoters and initially identified as the phorbol ester tumor promoter response element (TRE). Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. All three form heterodimers among themselves and with c-Fos and other members of the Fos gene family. Studies suggest that the two forms of Jun D may be due to internal initiation of translation.
Alternative Name:
Transcription factor jun-D, JUN D
Application Dilution: WB: 1:500~1:1000, IHC: 1:50~1:200
Specificity: p-JunD (S255) polyclonal antibody detects endogenous levels of JunD protein only when phosphorylated at Ser255
Immunogen:
Synthetic phosphopeptide derived from human JunD around the phosphorylation site of Serine 255.
MW: ~ 35 kDa
Swis Prot.: P17535
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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