K2P4.1 polyclonal, anti-human, mouse

Background:
Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro), raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity).

Alternative Name:
TRAAK, Two pore K(+) channel KT4.1, KCNK4, TRAAK, K2p4.1, K2P4.1 potassium channel, KCNK 4, MGC144821, Potassium channel subfamily K member 4, Potassium inwardly rectifying channel subfamily K member 4, TRAAK, TRAAK1, TRAAKt, TWIK related arachidonic acid stimulated potassium channel protein, Two pore K(+) channel KT4.1, Two pore K+ channel KT4.1, Two pore potassium channel KT4.1,

Application Dilution:
WB:1:500
IHC:1:50-1:200
FC:1:50-1:100

Specificity: K2P4.1 polyclonal antibody detects endogenous levels of K2P4.1 protein.

Immunogen:
Synthetic peptide within human K2P4.1 aa 320-380.

MW: 43 kDa

Swiss-Prot: Q9NYG8(Human)

Purification & Purity:
Peptide affinity purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.