Kallikrein 6 polyclonal, anti-human

Quantity: 100 µg

Background:
KLK6(Kallikrein-related peptidase 6), also called KALLIKREIN 6, NEUROSIN, PROTEASE M, ZYME or PRSS9, is a protein that in humans is encoded by the KLK6 gene. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. Northern blot analysis revealed that the PRSS9 mRNA was expressed in several primary tumors and cell lines from mammary, prostate, and ovarian cancers, but was not detected in any metastases of these cancers. The KLK6 gene is mapped on 19q13.41. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Upon cellular stress, neurosin was released from mitochondria to the cytosol, which resulted in the increase of degraded alpha-synuclein species. Neurosin may play a significant role in physiologic alpha-synuclein degradation and also in the pathogenesis of synucleinopathies.

Description:
Rabbit IgG polyclonal antibody for Kallikrein-6 (KLK6) detection. Tested with WB, IHC-P, ICC in Human.

Synonyms:
Bssp antibody, hK 6 antibody, hK6 antibody, Kallikrein 6 precursor antibody, Kallikrein related peptidase 6 antibody, Kallikrein-6 antibody, Kallikrein6 antibody, KLK 6 antibody, Klk 7 antibody, KLK 9 antibody, Klk29 antibody, Klk6 antibody, KLK6_HUMAN antibody, Klk7 antibody, KLK9 antibody, MGC9355 antibody, mGK 1 antibody, mGK1 antibody, MSP antibody, Neurosin antibody, Protease M antibody, Protease serine 18 antibody, Protease serine 9 antibody, PRSS 18 antibody, PRSS 9 antibody, PRSS18 antibody, PRSS9 antibody, Serine protease 18 antibody, Serine protease 9 antibody, SP 59 antibody, SP59 antibody, Tissue kallikrein antibody, TK antibody, Zyme antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human Kallikrein 6(227-244aa YTNVCRYTNWIQKTIQAK).

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB, IHC-P, ICC

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.