KappaB ras2 polyclonal, anti-human, mouse, rat
€484.00
In stock
SKU
253406
Protein Family: Enzymes
Pathway and Disease: Signaling Molecules and Interaction
Description:
KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.
Alternate Names: KappaB ras2, NF-kappaB inhibitor-interacting Ras like protein 2, kappaB-ras2, NKIRAS2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_060065
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KappaB ras2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Pathway and Disease: Signaling Molecules and Interaction
Description:
KappaB ras-1 (kappaB-ras-1) and kappaB-ras-2 are two small proteins that similar to Ras-like small GTPases that associate with IkappaB (IkappaB), an inhibitor of the transcription factor NF-kappaB. IkappaB exists in two homologous forms, IkappaB-alpha and IkappaB-beta, although IkappaB-beta contains a unique 47-amino acid region within its ankyrin domain. While inactive IkappaB-alpha-NF-kappaB complexes can shuttle in and out of the nucleus, IkappaB-beta-NF-kappaB complexes are retained exclusively in the cytoplasm. It is suggested that kappaB-ras proteins preferentially bind to the IkappaB-beta form through this unique insert within the ankyrin region, thus modulating the cellular location of IkappaB-beta and regulating the rate of degradation of IkappaB-beta. This antibody is specific for kappaB-ras2 and has no cross-reactivity to kappaB-ras1.
Alternate Names: KappaB ras2, NF-kappaB inhibitor-interacting Ras like protein 2, kappaB-ras2, NKIRAS2
Application Notes: E: 1:500-1:1,000; WB: 1:100-1:500
Accession No.: NP_060065
Antigen: KLH-conjugated synthetic peptide encompassing a sequence within human KappaB ras2.
Format: Each vial contains 0.1 ml IgG in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography.
Storage:
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
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