Karyopherin Alpha2 polyclonal antibody, anti-human, mouse, rat
€0.00
In stock
SKU
BT-AP04734
Catalog Number: BT-AP04734
Size(s): 20μL, 50μL, 100μL
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Application(s): WB, IHC-p, ELISA
Datasheet
Request Information
Size(s): 20μL, 50μL, 100μL
Isotype: Rabbit IgG
Reactivity: human, mouse, rat
Application(s): WB, IHC-p, ELISA
Datasheet
Request Information
Background:
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 (karyopherin subunit alpha 2) protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
Research Area: Immunology
Synonyms: KPNA2, RCH1, SRP1, Importin subunit alpha-2, Karyopherin subunit alpha-2, RAG cohort protein 1, SRP1-alpha
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage:
-20°C for 1 year
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 (karyopherin subunit alpha 2) protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants.
Research Area: Immunology
Synonyms: KPNA2, RCH1, SRP1, Importin subunit alpha-2, Karyopherin subunit alpha-2, RAG cohort protein 1, SRP1-alpha
Immunogen: The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration: 1 mg/ml
Storage:
-20°C for 1 year
| Is Featured? | No |
|---|
Write Your Own Review