KAT1 (HAT1) polyclonal (N-term), anti-human
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In stock
SKU
AC-AP1079a
Catalog Number: AC-AP1079a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5768
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB5768
Applications: WB
Datasheet
Request Information
Background:
Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.
Other Names:
Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase 1, HAT1, KAT1
Target/Specificity:
This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-58 amino acids from the N-terminal region of human KAT1 (HAT1).
Antigen Region:
27-58
Antigen Type: Synthetic Peptide
Gene Name: HAT1
Gene ID: 8520
Primary Accession: O14929
NCBI Accession: NP_003633.1
Other Accession: Q5M939; Q8BY71
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.
Other Names:
Histone acetyltransferase type B catalytic subunit, Histone acetyltransferase 1, HAT1, KAT1
Target/Specificity:
This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-58 amino acids from the N-terminal region of human KAT1 (HAT1).
Antigen Region:
27-58
Antigen Type: Synthetic Peptide
Gene Name: HAT1
Gene ID: 8520
Primary Accession: O14929
NCBI Accession: NP_003633.1
Other Accession: Q5M939; Q8BY71
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
| Is Featured? | No |
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