KAT13A/SRC1 polyclonal, anti-human

Quantity: 100 µg

Background:
The nuclear receptor coactivator 1 (NCOA1), also known as SRC1, is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression. It has been found that NCOA1 can enhance the transcriptional activity of ligand-bound PGR but does not alter the basal activity of the target promoter. It also enhances estrogen receptor, glucocorticoid receptor, thyroid hormone receptor, and retinoid X receptor transcriptional activities through their cognate DNA response elements in the presence of hormone. What’s more, SRC1 may play a role as a bridging molecule between nuclear hormone receptors and general transcription factors.

Description:
Rabbit IgG polyclonal antibody for Nuclear receptor coactivator 1 (NCOA1) detection. Tested with WB in Human.

Synonyms:
ASV antibody, bHLHe74 antibody, c SRC antibody, Class E basic helix-loop-helix protein 74 antibody, F SRC 1 antibody, Hin 2 protein antibody, Hin2 protein antibody, MGC129719 antibody, MGC129720 antibody, mNRC 1 antibody, NCoA 1 antibody, NCoA-1 antibody, Ncoa1 antibody, NCOA1_HUMAN antibody, Nuclear receptor coactivator 1 antibody, Nuclear receptor coactivator protein 1 antibody, NY REN 52 antigen antibody, p60 Src antibody, pp60c src antibody, Protein Hin 2 antibody, Protein Hin-2 antibody, Protein Hin2 antibody, Proto oncogene tyrosine protein kinase Src antibody, Renal carcinoma antigen NY REN 52 antibody, Renal carcinoma antigen NY-REN-52 antibody, RIP 160 antibody, RIP160 antibody, SRC 1 antibody, SRC-1 antibody, Steroid receptor coactivator 1 antibody, v src avian sarcoma (Schmidt Ruppin A 2) viral oncogene homolog antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human KAT13A recombinant protein (Position: H614-Q826). Human KAT13A shares 92% amino acid (aa) sequence identity with mouse KAT13A.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.