KAT2A/GCN5 polyclonal, anti-human

Quantity: 100 µg

Background:
Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene. It is mapped to 17q21. KAT2A, or GCN5, GCN5L2, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. The GCN5 protein, a regulator of transcription activation in yeast, promotes maximal levels of transcription by 2 transcriptional activators, GCN4 and the HAP2-HAP3-HAP4 complex. The GCN4 protein activates transcription of a large number of amino acid biosynthetic genes under limiting amino acid conditions and the HAP2-HAP3-HAP4 complex is thought to mediate transcription of genes involved in respiratory functions. GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner.

Description:
Rabbit IgG polyclonal antibody for Histone acetyltransferase KAT2A (KAT2A) detection. Tested with WB in Human.

Synonyms:
1110051E14Rik antibody, AW212720 antibody, EC 2.3.1.48 antibody, GCN 5 antibody, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2 antibody, Gcn5 antibody, GCN5 general control of amino-acid synthesis 5-like 2 (yeast) antibody, GCN5L2 antibody, general control of amino acid synthesis 5-like 2 antibody, General control of amino acid synthesis protein 5-like 2 antibody, General control of amino acid synthesis, yeast, homolog-like 2 antibody, HGCN5 antibody, Histone acetyltransferase GCN5 antibody, Histone acetyltransferase KAT2A antibody, hsGCN5 antibody, K(lysine) acetyltransferase 2A antibody, KAT2 A antibody, KAT2A antibody, KAT2A_HUMAN antibody, Lysine acetyltransferase 2A antibody, MGC102791 antibody, PCAF-b antibody, STAF97 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the N-terminus of human KAT2A/GCN5 (75-106aa DPARPGLSQQQRASQRKAQVRGLPRAKKLEKL), identical to the related mouse and rat sequences.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.