KCNA10 Polyclonal Antibody

Background:
KCNA10 (Potassium Voltage-Gated Channel Subfamily A Member 10) is a Protein Coding gene. Among its related pathways are Potassium Channels and Transmission across Chemical Synapses. GO annotations related to this gene include ion channel activity and intracellular cyclic nucleotide activated cation channel activity. An important paralog of this gene is KCNA4.Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It is specifically regulated by cGMP and postulated to mediate the effects of substances that increase intracellular cGMP. This gene is intronless, and the gene is clustered with genes KCNA2 and KCNA3 on chromosome 1.

Research Area: Cancer, Metabolism, Signal Transduction

Synonyms:
Cyclic GMP gated potassium channel, KCA10, Kcn 1, Kcn1, KCNA 10, KCNA10, Kv1.8, Potassium voltage gated channel shaker related subfamily member 10, Potassium voltage gated channel subfamily A member 10, Potassium voltage-gated channel subfamily A member 10, Voltage gated potassium channel subunit Kv1.8, Voltage-gated potassium channel subunit Kv1.8

Immunogen: Synthetic peptide of human KCNA10

Swissprot: Q16322
Gene Accession: NP005540

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.66 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.