KCNA2 polyclonal, anti-human, mouse

Background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.

Synonyms: EIEE32, HBK5, HK4, HUKIV, KV1.2, MK2, NGK1, RBK2

Cellular Location: Cell junction Cell membrane Cell projection Endoplasmic reticulum membrane Membrane Multi-pass membrane protein axon dendrite lamellipodium membrane presynaptic cell membrane synapse synaptosome

Immunogen:
Recombinant protein of human KCNA2

Gene Symbol: KCNA2

Gene ID: 3737

Swiss prot: P16389

Calculated MW: 57kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200, IF 1:50-100,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.