KCNA5 polyclonal, anti-human

Quantity: 100 µg

Background:
Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a protein that in humans is encoded by the KCNA5 gene. Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization, thereby contributing to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Mutations in this gene have been related to both atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Description:
Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily A member 5 (KCNA5) detection. Tested with WB in Human.

Synonyms:
ATFB7 antibody, cardiac potassium channel antibody, HCK1 antibody, HK2 antibody, HPCN1 antibody, insulinoma and islet potassium channel antibody, KCNA5 antibody, KCNA5_HUMAN antibody, Kv1 antibody, KV1.5 antibody, MGC117058 antibody, MGC117059 antibody, MGC25248 antibody, PCN1 antibody, Potassium channel 1 antibody, Potassium channel insulinoma and islet cell antibody, Potassium channel, insulinoma and islet cell antibody, Potassium channel, voltage-gated, shaker-related subfamily, member 5 antibody, Potassium voltage gated channel shaker related subfamily member 5 antibody, Potassium voltage gated channel subfamily A member 5 antibody, Potassium voltage-gated channel subfamily A member 5 antibody, Voltage-gated potassium channel HK2 antibody, voltage-gated potassium channel protein Kv1.5 antibody, Voltage-gated potassium channel subunit Kv1.5 antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
A synthetic peptide corresponding to a sequence at the C-terminus of human KCNA5 (583-613aa LEKCNVKAKSNVDLRRSLYALCLDTSRETDL), different from the related mouse and rat sequences by two amino acids.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.