KCNA5 Polyclonal Antibody

Background:
Potassium channels represent the most complex class of voltage-gated ino channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting membrane potential of beta cells after depolarization and thereby contribute to the regulation of insulin secretion. This gene is intronless, and the gene is clustered with genes KCNA1 and KCNA6 on chromosome 12. Defects in this gene are a cause of familial atrial fibrillation type 7 (ATFB7).

Research Area: Cancer, Cardiovascular, Metabolism, Neuroscience

Synonyms:
ATFB7, cardiac potassium channel, HCK1, HK2, HPCN1, insulinoma and islet potassium channel, KCNA5, KCNA5, KV1.5, PCN1, potassium channel 1, Potassium channel, insulinoma and islet cell, Potassium channel, voltage-gated, shaker-related subfamily, member 5, Potassium voltage gated channel subfamily A member 5, Potassium voltage-gated channel subfamily A member 5, Voltage-gated potassium channel HK2, voltage-gated potassium channel protein Kv1.5, Voltage-gated potassium channel subunit Kv1.5

Immunogen: Recombinant protein of human KCNA5

Swissprot: P22460
Gene Accession: BC099665

Calculated MW: 67 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.4 mg/mL
Dilution: WB 1:500-1:2000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-11671/sc-11675/sc-11672/sc-25681