KCNH1 polyclonal, anti-human, mouse, rat

Background:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit of a voltage-gated non-inactivating delayed rectifier potassium channel. It is activated at the onset of myoblast differentiation. The gene is highly expressed in brain and in myoblasts. Overexpression of the gene may confer a growth advantage to cancer cells and favor tumor cell proliferation. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.

Synonyms: EAG, EAG1, Kv10.1, TMBTS, ZLS1, h-eag, hEAG1

Cellular Location: Cell membrane Early endosome membrane Multi-pass membrane protein Nucleus inner membrane

Immunogen:
Recombinant protein of human KCNH1

Gene Symbol: KCNH1

Gene ID: 3756

Swiss prot: O95259

Calculated MW: 111kDa

Recommended dilution:
WB 1:500-2000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.