KCNH2 polyclonal, anti-human, rat

Quantity: 100 µg

Background:
KCNH2, also known as HERG or KV11.1, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel. It is mapped to 7q36.1. KCNH2 forms the major portion of one of the ion channel proteins (the 'rapid' delayed rectifier current (IKr)) that conducts potassium (K+) ions out of the muscle cells of the heart (cardiac myocytes), and this current is critical in correctly timing the return to the resting state (repolarization) of the cell membrane during the cardiac action potential. What’s more, KCNH2 channels show gating properties consistent with many of the outwardly rectifying potassium channels, but they also have an inactivation mechanism that attenuates efflux during depolarization.

Description:
Rabbit IgG polyclonal antibody for Potassium voltage-gated channel subfamily H member 2 (KCNH2) detection. Tested with WB in Human, Rat.

Synonyms:
eag homolog antibody, Eag-related protein 1 antibody, ERG antibody, ERG-1 antibody, ERG1 antibody, Ether a go go related potassium channel protein antibody, Ether-a-go-go-related gene potassium channel 1 antibody, Ether-a-go-go-related protein 1 antibody, H ERG antibody, H-ERG antibody, HERG 1 antibody, HERG antibody, hERG-1 antibody, HERG1 antibody, KCNH2 antibody, KCNH2_HUMAN antibody, Kv11.1 antibody, LQT 2 antibody, LQT2 antibody, Potassium channel HERG antibody, Potassium voltage gated channel subfamily H (eag related) member 2 antibody, Potassium voltage-gated channel subfamily H member 2 antibody, SQT1 antibody, Voltage gated potassium channel, subfamily H, member 2 antibody, Voltage-gated potassium channel subunit Kv11.1 antibody, Voltagegated potassium channel, subfamily H, member 2 antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human KCNH2 recombinant protein (Position: L856-S1159). Human KCNH2 shares 92% amino acid (aa) sequence identity with both mouse and rat KCNH2.E.coli-derived human KCNH2 recombinant protein (Position: L856-S1159). Human KCNH2 shares 92% amino acid (aa) sequence identity with both mouse and rat KCNH2.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, rat

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.