KCNK10 Polyclonal Antibody

Background:
The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations, and is stimulated strongly by arachidonic acid and to a lesser degree by membrane stretching, intracellular acidification, and general anaesthetics. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
KCNK10 (Potassium Two Pore Domain Channel Subfamily K Member 10) is a Protein Coding gene. Diseases associated with KCNK10 include Dentin Sensitivity. Among its related pathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. GO annotations related to this gene include potassium channel activity and potassium ion leak channel activity. An important paralog of this gene is KCNK2.

Research Area: Neuroscience

Synonyms:
2P domain potassium channel TREK2, K2p10.1, KCNK10, KCNKA, Outward rectifying potassium channel protein TREK 2, Outward rectifying potassium channel protein TREK-2, Potassium channel subfamily K member 10, Potassium channel TREK 2, TREK 2, TREK 2 K, TREK 2 K(+) channel subunit, TREK-2 K(+) channel subunit, TREK2, TWIK related K+ channel 2

Immunogen: Synthetic peptide of human KCNK10

Swissprot: P57789
Gene Accession: NP066984

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.96 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.