KCNMA1 polyclonal, anti-human, mouse, rat

Quantity: 100 µg

Background:
Calcium-activated potassium channel subunit alpha-1 also known as KCa1.1, or BK channel for short, is a voltage gated potassium channel encoded by the KCNMA1 gene and characterized by their large conductance of potassium ions (K+) through cell membranes. This gene is located on 10q22.3. BK channels are activated (opened) by changes in membrane electrical potential and/or by increases in concentration of intracellular calcium ion (Ca2+). It is essential for the regulation of several key physiological processes including smooth muscle tone and neuronal excitability. BK channels also contribute to the behavioral effects of ethanol in the worm C. elegans under high concentrations (> 100 mM, or approximately 0.50% BAC).It remains to be determined if BK channels contribute to intoxication in humans.

Description:
Rabbit IgG polyclonal antibody for Calcium-activated potassium channel subunit alpha-1 (KCNMA1) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Synonyms:
subfamily M subunit alpha-1 antibody, bA205K10.1 antibody, BK channel antibody, BKCA alpha antibody, BKCA alpha subunit antibody, BKTM antibody, Calcium activated potassium channel subfamily M subunit alpha 1 antibody, Calcium activated potassium channel subunit alpha 1 antibody, Calcium-activated potassium channel antibody, Calcium-activated potassium channel subunit alpha-1 antibody, DKFZp686K1437 antibody, Drosophila slowpoke like antibody, hSlo antibody, K(VCA)alpha antibody, KCa1.1 antibody, KCMA1_HUMAN antibody, KCNMA 1 antibody, KCNMA antibody, KCNMA1 antibody, Large conductance calcium activated potassium channel subfamily M alpha member 1 antibody, Maxi K antibody, Maxi K channel antibody, Maxi Potassium channel alpha antibody, MaxiK antibody, MGC71881 antibody, OTTHUMP00000060198 antibody, OTTHUMP00000064154 antibody, OTTHUMP00000064155 antibody, OTTHUMP00000064156 antibody, OTTHUMP00000064157 antibody, OTTHUMP00000064158 antibody, OTTHUMP00000064159 antibody, OTTHUMP00000064160 antibody, OTTHUMP00000064161 antibody, OTTHUMP00000064162 antibody, OTTHUMP00000064164 antibody, OTTHUMP00000064165 antibody, Potassium large conductance calcium activated channel subfamily M alpha member 1 antibody, SAKCA antibody, Slo 1 antibody, SLO alpha antibody, SLO antibody, Slo homolog antibody, Slo-alpha antibody, Slo1 antibody, Slowpoke homolog antibody, Stretch activated Kca channel antibody

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human KCNMA1 recombinant protein (Position: K124-Q467). Human KCNMA1 shares 99% amino acid (aa) sequence identity with both mouse and rat KCNMA1.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human, mouse, rat

Applications: WB, IHC-P

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.