KCNN2 Polyclonal Antibody

Background:
Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants.
KCNN2 (Potassium Calcium-Activated Channel Subfamily N Member 2) is a Protein Coding gene. Among its related pathways are Serotonergic synapse and Bile secretion. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is KCNN3.

Research Area: Neuroscience

Synonyms:
Apamin sensitive small conductance Ca2+ activated potassium, Apamin sensitive small conductance Ca2+ activated potassium channel, hSK2, KCa2.2, Kcnn2, Potassium intermediate/small conductance calcium activated, Potassium intermediate/small conductance calcium activated channel subfamily N member 2, SK2, SKCa 2, SKCa2, Small conductance calcium activated potassium channel, Small conductance calcium activated potassium channel protein 2, Small conductance calcium-activated potassium channel protein 2

Immunogen: Synthetic peptide of human KCNN2

Swissprot: Q9H2S1
Gene Accession: NP067627

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.78 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.