KCNN3 polyclonal, anti-human, mouse, rat
€388.00
In stock
SKU
BS7920
Background:
Small-conductance, calcium-activated K+ channels (SK channels) are activated in a voltage-independent manner, and they have a small unit conductance and high sensitivity to calcium. SK channels 1-3 contain intracellular N- and C- termini and 6 conserved transmembrane segments. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed. SK channels influence most excitable cells and participate in afterhyperpolarization (AHP) and spike-frequency adaptation. Human SK3 is a 731 amino acid protein that is expressed in muscles upon denervation, and it is a component of the presynaptic compartment in mature neuromuscular junctions. SK3 may also play a regulatory role in synaptic transmission.
Alternative Name:
hSK3, KCa2.3, Kcnn3, KCNN3_HUMAN, Potassium intermediate/small conductance calcium activated channel subfamily N member 3, SK3, SKCa 3, SKCa3, Small conductance calcium-activated potassium channel protein 3,
Application Dilution: WB: 1:500 - 1:2000
Specificity: KCNN3 polyclonal antibody detects endogenous levels of KCNN3 protein.
Immunogen:
Recombinant full length Human KCNN3.
MW: ~ 82 kDa
Swis Prot.: Q9UGI6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Small-conductance, calcium-activated K+ channels (SK channels) are activated in a voltage-independent manner, and they have a small unit conductance and high sensitivity to calcium. SK channels 1-3 contain intracellular N- and C- termini and 6 conserved transmembrane segments. SK1 expression is restricted to the brain whereas SK2 and SK3 are more widely expressed. SK channels influence most excitable cells and participate in afterhyperpolarization (AHP) and spike-frequency adaptation. Human SK3 is a 731 amino acid protein that is expressed in muscles upon denervation, and it is a component of the presynaptic compartment in mature neuromuscular junctions. SK3 may also play a regulatory role in synaptic transmission.
Alternative Name:
hSK3, KCa2.3, Kcnn3, KCNN3_HUMAN, Potassium intermediate/small conductance calcium activated channel subfamily N member 3, SK3, SKCa 3, SKCa3, Small conductance calcium-activated potassium channel protein 3,
Application Dilution: WB: 1:500 - 1:2000
Specificity: KCNN3 polyclonal antibody detects endogenous levels of KCNN3 protein.
Immunogen:
Recombinant full length Human KCNN3.
MW: ~ 82 kDa
Swis Prot.: Q9UGI6
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.1% Sodium Azide, 50% Glycerol.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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