KCNT1 Polyclonal Antibody

Background:
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a sodium-activated potassium channel subunit which is thought to function in ion conductance and developmental signaling pathways. Mutations in this gene cause the early-onset epileptic disorders, malignant migrating partial seizures of infancy and autosomal dominant nocturnal frontal lobe epilepsy. Alternative splicing results in multiple transcript variants.

Research Area: Neuroscience

Synonyms:
bA100C15.2, EIEE14, ENFL5, KCa4.1, KCNT1, KCNT1, Potassium channel subfamily T member 1, Potassium channel, sodium activated subfamily T, member 1, Potassium channel, subfamily T, member 1 , Sequence like a calcium-activated K+ channel, SLACK , Slo2.2

Immunogen: Synthetic peptide of human KCNT1

Swissprot: Q5JUK3
Gene Accession: NP065873

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 0.9 mg/mL
Dilution: IHC 1:30-1:150, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.