KDM1B polyclonal, anti- antibody
€215.00
In stock
SKU
AC-ABV11381-50
Catalog Number: AC-ABV11381-50
Size: 50 µl
Host: Rabbit IgG
Applications: E
Datasheet
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Size: 50 µl
Host: Rabbit IgG
Applications: E
Datasheet
Request Information
Background:
KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
Other Names:
AOF1, LSD2, C6orf193
Primary Accession: Q8NB78
Gene Name: KDM1B
Gene ID: 221656
KDM1B is a histone demethylase that demethylates lysine 4 of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. KDM1B is able to demethylate both mono- and di-methylated lysine 4 of histone H3, but has no effect on tri-methylated lysine 4, mono-, di- or tri-methylated lysine 9, mono-, di- or tri-methylated lysine 27, mono-, di- or tri-methylated lysine 36 of histone H3, or on mono-, di- or tri-methylated lysine 20 of histone H4. KDM1B is also required for de novo DNA methylation of a subset of imprinted genes during oogenesis. It acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
Other Names:
AOF1, LSD2, C6orf193
Primary Accession: Q8NB78
Gene Name: KDM1B
Gene ID: 221656
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