KDM1B polyclonal (N-term), anti-human
€0.00
In stock
SKU
AC-AP21020a
Catalog Number: AC-AP21020a
Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB49895
Applications: WB
Datasheet
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Size: 80 µl, 400 µl
Isotype: Rabbit IgG
Clone Name: RB49895
Applications: WB
Datasheet
Request Information
Background:
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).
Other Names:
Lysine-specific histone demethylase 1B, 1---, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2, KDM1B, AOF1, C6orf193, LSD2
Target/Specificity:
This KDM1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 38-73 amino acids from the N-terminal region of human KDM1B.
Gene Name: KDM1B (HGNC:21577)
Gene ID: 221656
Primary Accession: Q8NB78
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri- methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys- 36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (By similarity).
Other Names:
Lysine-specific histone demethylase 1B, 1---, Flavin-containing amine oxidase domain-containing protein 1, Lysine-specific histone demethylase 2, KDM1B, AOF1, C6orf193, LSD2
Target/Specificity:
This KDM1B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 38-73 amino acids from the N-terminal region of human KDM1B.
Gene Name: KDM1B (HGNC:21577)
Gene ID: 221656
Primary Accession: Q8NB78
Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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