KDM3A (clone 2E1), anti-human
€0.00
In stock
SKU
BT-MCA2987
Catalog Number: BT-MCA2987
Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): WB, ICC
Datasheet
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Size(s): 50μL, 100μL
Isotype: Mouse IgG1
Reactivity: human
Application(s): WB, ICC
Datasheet
Request Information
Background:
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Research Area: Epigenetics and nuclear signaling
Synonyms: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A
Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.
Research Area: Epigenetics and nuclear signaling
Synonyms: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A
Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.
Formulation: Ascitic fluid containing 0.03% sodium azide.
Storage:
4°C|-20°C for long term storage
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