KDM5B polyclonal, anti-human
€388.00
In stock
SKU
BS70906
Background:
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Alternative Name:
Lysine-specific demethylase 5B, Cancer/testis antigen 31, CT31, PLU-1, RBP2-H1, JARID1B, PLU1, RBBP2H1
Application Dilution: WB: 1:500 - 1:2000
Specificity: KDM5B polyclonal antibody detects endogenous levels of KDM5B protein.
Immunogen:
Recombinant protein of human KDM5B.
MW: ~ 176 kDa
Swis Prot.: Q9UGL1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2.
Alternative Name:
Lysine-specific demethylase 5B, Cancer/testis antigen 31, CT31, PLU-1, RBP2-H1, JARID1B, PLU1, RBBP2H1
Application Dilution: WB: 1:500 - 1:2000
Specificity: KDM5B polyclonal antibody detects endogenous levels of KDM5B protein.
Immunogen:
Recombinant protein of human KDM5B.
MW: ~ 176 kDa
Swis Prot.: Q9UGL1
Purification & Purity:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Format:
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
For research use only, not for use in diagnostic procedure.
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