KDM5B Polyclonal Antibody

Background:
PLU-1 is a large (1,544 amino acid) nuclear protein that interacts with brain factor-1 (BF-1) and paired box 9 (PAX9), both of which are developmental transcription factors. PLU-1 belongs to the testis-cancer antigen group of proteins and is a member of the ARID family of DNA binding proteins. It is a multi-domain protein with strong transcriptional repression properties. PLU-1 shows restricted expression in adult tissues, with high expression in testis and transient expression in the pregnant mammary gland. Both the PLU-1 gene and the PLU-1 protein product are specifically upregulated in breast cancer. PLU-1 may be important in meiotic transcription because of its apparent association with chromatin.

Research Area: Cancer, Epigenetics and Nuclear Signaling

Synonyms:
Cancer/testis antigen 31, CT31, Histone demethylase JARID1B, JARID1B, Jumonji AT rich interactive domain 1B, Jumonji/ARID domain-containing protein 1B, Kdm5b, KDM5B, Lysine (K) specific demethylase 5B, Lysine demethylase 5B, Lysine specific demethylase 5B, Lysine-specific demethylase 5B, PLU-1, PLU1, PPP1R98, Protein phosphatase 1 regulatory subunit 98, PUT1, putative DNA/chromatin binding motif, RBBP2H1A, RBP2 like, RBP2-H1, Retinoblastoma-binding protein 2 homolog 1, Retinoblastoma-binding protein 2 homolog 1A

Immunogen: Synthetic peptide of human KDM5B

Swissprot: Q9UGL1
Gene Accession: NP_006609

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 1.5 mg/mL
Dilution: IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-31612/sc-31613/sc-67035