KDR polyclonal, anti-mouse, rat

Background:
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas.

Synonyms: CD309, FLK1, VEGFR, VEGFR2

Cellular Location: Cell junction Cell membrane Cytoplasm Cytoplasmic vesicle Early endosome Endoplasmic reticulum Nucleus Secreted Single-pass type I membrane protein

Immunogen:
Recombinant protein of human KDR

Gene Symbol: KDR

Gene ID: 3791

Swiss prot: P35968

Calculated MW: 152kDa

Recommended dilution:
WB 1:500-2000, IHC 1:50-200,

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.