Keap1 polyclonal, anti-human

Quantity: 100 µg

Background:
KEAP1 (KELCH-LIKE ECH-ASSOCIATED PROTEIN 1), is a protein that in humans is encoded by the Keap1 gene. The KIAA0132 gene is mapped on 19p13.2. Keap1 contains a central BTB/POZ domain and a C-terminal double glycine repeat (DGR), or Kelch, module. Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. In the presence of the electrophilic agent diethylmalate, Nrf2 activity is released from Keap1 and Nrf2 translocate to the nucleus. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which, in turn, facilitates the ubiquitination and subsequent proteolysis of Nrf2. Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.

Description:
Rabbit IgG polyclonal antibody for Kelch-like ECH-associated protein 1 (KEAP1) detection. Tested with WB in Human.

Synonyms:
Cytosolic inhibitor of Nrf2 antibody, INrf 2 antibody, INrf2 antibody, Keap 1 antibody, KEAP1 antibody, KEAP1_HUMAN antibody, Kelch like ECH associated protein 1 antibody, Kelch like family member 19 antibody, Kelch like protein 19 antibody, Kelch-like ECH-associated protein 1 antibody, Kelch-like protein 19 antibody, KIAA0132 antibody, KLHL 19 antibody, KLHL19 antibody, MGC10630 antibody, MGC1114 antibody, MGC20887 antibody, MGC4407 antibody, MGC9454 antibody.

Isotype: Rabbit polyclonal IgG

Immunogen:
E.coli-derived human Keap1 recombinant protein (Position: E25-E205). Human Keap1 shares 96.7% and 97.2% amino acid (aa) sequence identity with mouse and rat Keap1, respectively.

Form: Lyophilized; Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Specificity:
No cross reactivity with other proteins.

Reactivity: Reacts with: human

Applications: WB

Reconstitution:
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Storage: At -20˚C for one year. After reconstitution, at 4˚C for one month. It can also be aliquotted and stored frozen at -20˚C for a longer time. Avoid repeated freezing and thawing.