Keratin 17 polyclonal, anti-human, mouse, rat
€470.00
In stock
SKU
AC-AP50190
Catalog Number: AC-AP50190
Size: 100 µl
Host: Rabbit
Applications: WB, IF, IHC
Datasheet
Request Information
Size: 100 µl
Host: Rabbit
Applications: WB, IF, IHC
Datasheet
Request Information
Background:
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
Other Names:
Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
Antigen Type: Synthetic Peptide
Antigen Type: KRT17
Gene ID: 3872
Primary Accession: Q04695
May play a role in the formation and maintenance of various skin appendages, specifically in determining shape and orientation of hair. May be a marker of basal cell differentiation in complex epithelia and therefore indicative of a certain type of epithelial "stem cells". May act as an autoantigen in the immunopathogenesis of psoriasis, with certain peptide regions being a major target for autoreactive T-cells and hence causing their proliferation. Required for the correct growth of hair follicles, in particular for the persistence of the anagen (growth) state. Modulates the function of TNF-alpha in the specific context of hair cycling. Regulates protein synthesis and epithelial cell growth through binding to the adapter protein SFN and by stimulating Akt/mTOR pathway. Involved in tissue repair (By similarity).
Other Names:
Keratin, type I cytoskeletal 17, Cytokeratin-17, CK-17, Keratin-17, K17, KRT17
Antigen Type: Synthetic Peptide
Antigen Type: KRT17
Gene ID: 3872
Primary Accession: Q04695
| Is Featured? | No |
|---|
Write Your Own Review