KHSRP polyclonal, anti-human, mouse, rat

Background:
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Alternative Name:
FUSE-binding protein 2, KSRP, KHSRP, FUBP2, Far upstream element-binding protein 2, FBP2, FUBP2, FUBP2, FUSE binding protein 2, FUSE-binding protein 2, KH type splicing regulatory protein (FUSE binding protein 2), KH type splicing regulatory protein, KH type-splicing regulatory protein, KHSRP, KSRP, p75,

Application Dilution:
WB:1:500-1:2,000
ICC/IF:1:50-1:200
IHC:1:50-1:200
IP:1:10-1:50

Specificity: KHSRP polyclonal antibody detects endogenous levels of KHSRP protein.

MW: 73 kDa

Swiss-Prot: Q92945(Human) Q3U0V1(Mouse) Q99PF5(Rat)

Purification & Purity:
ProA affinity purified

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.