KHSRP polyclonal, anti-human, mouse, rat

Background:
Binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.

Alternative Name:
Far upstream element-binding protein 2, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, KHSRP, FUBP2

Application Dilution: WB: 1:500-1:2000, ICC: 1:50-1:200, IHC: 1:50-1:200, IP: 1:10-1:50

Specificity: This antibody detects endogenous levels of KHSRP and does not cross-react with related proteins.

Immunogen:
Recombinant protein within human KHSRP aa 1-150.

MW: ~ 73 kDa

Swis Prot.: Q92945

Purification & Purity:
Protein A affinity purified.

Format:
Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Storage:
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

For research use only, not for use in diagnostic procedure.