KIF3A Polyclonal Antibody

Background:
Kinesin-like protein KIF3Ais aproteinthat in humans is encoded by theKIF3Agene. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.

Research Area: Cancer, Neuroscience, Signal Transduction, Stem Cells

Synonyms:
KIF 3, KIF 3A, KIF3, Kif3a, KIF3A, Kifl, Kinesin family member 3A, Kinesin family protein 3, Kinesin family protein 3A, Kinesin like protein KIF 3A, Kinesin like protein KIF3A, Kinesin-like protein KIF3A, Kns3, Microtubule plus end directed kinesin motor 3A, Microtubule plus end-directed kinesin motor 3A

Immunogen: Recombinant protein of human KIF3A

Swissprot: Q9Y496
Gene Accession: BC045542

Calculated MW: 80 kDa

Purification Method: Affinity purification

Buffer: PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Concentration: 0.2 mg/mL
Dilution: WB 1:500-1:2000, IHC 1:50-1:200

Storage:
Store at -20°C. Avoid freeze / thaw cycles.

Alternative for product with catalog number:
sc-18745/sc-50457