Kininogen 1 polyclonal, anti-human, mouse

Background:
(1) Kininogens are inhibitors of thiol proteases, (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII, (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes, (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action), (5) LMW-kininogen inhibits the aggregation of thrombocytes, (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

Alternative Name:
HMWK, KNG1, BDK, KNG, Alpha-2-thiol proteinase inhibitor, BDK, BK, Bradykinin, Bradykinin included, Fitzgerald factor, FLAUJEAC FACTOR, High molecular weight kininogen, HMWK, Ile-Ser-Bradykinin, Kallidin I, Kallidin II, KNG, KNG1, KNG1, Low molecular weight growth-promoting factor, WILLIAMS FACTOR, Williams-Fitzgerald-Flaujeac factor antibody

Application Dilution:
WB:1:500-1:2,000
IHC:1:50-1:200

Specificity: Kininogen 1 polyclonal antibody detects endogenous levels of Kininogen 1 protein.

Immunogen:
Recombinant protein within human Kininogen 1 aa 500-644.

MW: Predicted molecular weight: 48, 72 kDa

Swiss-Prot: P01042 Human

Purification & Purity:
Protein A purified.

Format:
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Storage:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

For research use only, not for use in diagnostic procedure.