KIR2DL2 Antibody (C-term) Blocking peptide
€363.00
In stock
SKU
AC-BP5762b
Background:
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response.
Other Names:
Killer cell immunoglobulin-like receptor 2DL2, CD158 antigen-like family member B1, MHC class I NK cell receptor, Natural killer-associated transcript 6, NKAT-6, p58 natural killer cell receptor clone CL-43, p58 NK receptor CL-43, CD158b1, KIR2DL2, CD158B1, NKAT6
Gene Name: KIR2DL2 (HGNC:6330)
Gene ID: 3803
Primary Accession: P43627
Other Accession: NP_055034.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response.
Other Names:
Killer cell immunoglobulin-like receptor 2DL2, CD158 antigen-like family member B1, MHC class I NK cell receptor, Natural killer-associated transcript 6, NKAT-6, p58 natural killer cell receptor clone CL-43, p58 NK receptor CL-43, CD158b1, KIR2DL2, CD158B1, NKAT6
Gene Name: KIR2DL2 (HGNC:6330)
Gene ID: 3803
Primary Accession: P43627
Other Accession: NP_055034.2
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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