KIR2DL5A Polyclonal Antibody

Background:
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Synonyms:
CD158F, CD158f1, KI2LA, Killer cell immunoglobulin-like receptor 2DL5A, killer cell immunoglobulin-like receptor KIR2DL5A, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A, killer-cell Ig-like receptor, KIR2DL5, KIR2DL5.1, KIR2DL5.3, KIR2DL5A, KIR2DL5B

Immunogen: Synthetic peptide of human KIR2DL5A

Swissprot: Q8N109
Gene Accession: NP065396

Calculated MW: 41 kDa
Observed MW: Refer to figures

Purification Method: Antigen affinity purification

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Concentration: 1.2 mg/mL
Dilution: WB 1:1000-1:5000, IHC 1:40-1:200, ELISA 1:5000-1:10000

Storage:
Store at -20°C. Avoid freeze / thaw cycles.