KIR3DP1 Antibody (N-term) Blocking peptide
€363.00
In stock
SKU
AC-BP5569a
Background:
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response. This gene is one of the'framework' loci that is present on all haplotypes. This locusrepresents an alternate copy of KIR3DP1 that is represented in asmall percentage of the population and may encode a functionalprotein. The other copy is considered to be a pseudogene. [providedby RefSeq].
Other Names:
Putative killer cell immunoglobulin-like receptor like protein KIR3DP1, CD158c, KIR3DP1, CD158C, KIR2DS6, KIR48, KIRX
Primary Accession: A8MWS1
Other Accession: NP_001015070.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Killer cell immunoglobulin-like receptors (KIRs) aretransmembrane glycoproteins expressed by natural killer cells andsubsets of T cells. The KIR genes are polymorphic and highlyhomologous and they are found in a cluster on chromosome 19q13.4within the 1 Mb leukocyte receptor complex (LRC). The gene contentof the KIR gene cluster varies among haplotypes, although several'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,KIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofextracellular immunoglobulin domains (2D or 3D) and by whether theyhave a long (L) or short (S) cytoplasmic domain. KIR proteins withthe long cytoplasmic domain transduce inhibitory signals uponligand binding via an immune tyrosine-based inhibitory motif(ITIM), while KIR proteins with the short cytoplasmic domain lackthe ITIM motif and instead associate with the TYRO protein tyrosinekinase binding protein to transduce activating signals. The ligandsfor several KIR proteins are subsets of HLA class I molecules;thus, KIR proteins are thought to play an important role inregulation of the immune response. This gene is one of the'framework' loci that is present on all haplotypes. This locusrepresents an alternate copy of KIR3DP1 that is represented in asmall percentage of the population and may encode a functionalprotein. The other copy is considered to be a pseudogene. [providedby RefSeq].
Other Names:
Putative killer cell immunoglobulin-like receptor like protein KIR3DP1, CD158c, KIR3DP1, CD158C, KIR2DS6, KIR48, KIRX
Primary Accession: A8MWS1
Other Accession: NP_001015070.1
Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
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