Kir6.2 polyclonal, anti-human

Background:
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Synonyms: KCNJ11,BIR,HHF2,IKATP,MODY13,PHHI,TNDM3,ATP-sensitive inward rectifier potassium channel 11

Cellular Location: Cell membrane

Immunogen:
A synthetic peptide of human Kir6.2

Gene Symbol: Kir6.2

Gene ID: 3767

Swiss prot: Q14654

Calculated MW: 44/33kDa

Recommended dilution:
WB 1:5000-8000

Purity:
Affinity purification

Storage Buffer:
Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.

Storage:
Store at -20℃. Avoid freeze / thaw cycles.